By Staff Writer

First discovered in 1953, SAM-e or S-adenosylmethionine , a synthetic compound formed naturally in the body, originally coming from energy-producing compounds usually found inside the cells of the body.  It is involved in different essential biochemical processes such as cell maintenance and nerve function.  SAM-e is widely believed to be very effective in combating osteoarthritis, depression and liver disease, among others.

  • Depression.  Antidepressants usually work by slowing down the process of removal of certain number of chemicals in the brain which are essential for brain function.  According to research, SAM-e is a very effective supplement for depression because it increases the production of essential neurotransmitters such as serotonin (modulates anger, aggression, body temperature, mood and sleep among others) and dopamine (often associated with the pleasure system of the brain).  People who take SAM-e to alleviate depression have reported to have a more positive mood and better emotional well-being.
  • Osteoarthritis.  Osteoarthritis is a group of abnormalities and dysfunctions in the body normally found to be the cause of the degradation of the joints.  Because of these abnormalities patients with osteoarthritis often find it difficult and painful to walk and move around.  Research has shown that SAM-e aids in effective pain relief.  Many prefer SAM-e over other medical supplements because it has been reported to have fewer side-effects, unlike other pain relief medicines.
  • Liver disease.  Degradation of the liver stems from excessive alcohol intake, and could lead to several diseases and complications.  The liver naturally produces SAM-e, but a damaged liver can find it hard to produce this substance, hence the need for supplementary medicines.  SAM-e is also found to cure liver diseases such as cirrhosis, which is normally caused by alcoholism.  In one trial, people who took SAM-e to cure cirrhosis have been seen to reduce the death rate by half and have less need for liver transplant, compared to people who were simply given a placebo.
  • Fibromyalgia.  Fibromyalgia is a condition characterized by severe muscle and connective tissue pain, as well as a very high sensitivity to gentle touch.  It has also been reportedly causing debilitating fatigue, sleep disturbance and joint stiffness to people stricken with this disease.  Research has shown that SAM-e is beneficial to people with Fibromyalgia in reducing fatigue and eliminating chronic pain experienced throughout the body.  Moreover, people who took SAM-e were seen to have a lighter mood than people who have not taken the medication.  But current research is far from conclusive in determining the relation of SAM-e with curing this disease.  Notwithstanding, previously mentioned researches have noted such benefits.

Like any other medication, it is best to consult with your doctor first before introducing SAM-e into your system.  Your doctor knows the appropriate dosage for these supplements, so you shouldn't go out simply taking these medicines just because you know these benefits.  Still, a more healthy and well-balanced diet effectively complements any medication available in the market today.